Effects of mitomycin-C on tear film function following photorefractive keratectomy for mild-to-moderate myopia

Background: Mitomycin C (MMC) is used to prevent corneal opacity after photorefractive keratectomy (PRK). This study sought determine the effect of MMC on tear film function PRK in eyes with mild-to-moderate myopia.Methods: prospective, contralateral eye comparison was conducted 30 15 patients low-to-moderate myopia referred Alzahra Eye Hospital, Zahedan, Iran. The control group underwent a balanced salt solution, while fellow intervention 0.02% for 25 s. breakup time test (TBUT) and basic Schirmer results groups were compared at baseline 1, 3, 6 months postoperatively. Tear osmolarity recorded 3 Results: mean ± standard deviation (SD) age participants 27.53 7.04 years. No statistically significant differences observed means SDs osmolarity, TBUT, values (all P > 0.05) between MMC-treated untreated during postoperative follow-up. comparable both follow-ups 0.05). Conclusions: Single application dose (0.02%) s did not change stability, production, or variation dynamics up postoperatively myopia. Future longitudinal studies longer follow-up larger sample size are warranted confirm our findings.